Interventional

Inferior Petrosal Sinus Sampling (IPSS) Calculator

IPSS sampling calculator for adult ACTH-dependent hypercortisolism: basal and post-CRH ACTH ratios, optional prolactin and method-specific normalization. No automated surgical-side selection.

References

  1. Siddiq F et al. Consensus Guidelines on Inferior Petrosal Sinus Sampling. SVIN 2026. Important Lab Values, Figure 5 and timing: inclusive ACTH/PRL criteria and concurrent normalization.
  2. Sharma ST, Raff H, Nieman LK. Prolactin as a marker of successful catheterization during IPSS (2011). Study analysis: dominant post-CRH ACTH normalized by ipsilateral basal PRL.
  3. Fleseriu M et al. Consensus on diagnosis and management of Cushing's disease: a guideline update (2021). IPSS clinical context, false results and limits of right-left localization; accepted manuscript pp.13,16–18.
  4. Oldfield EH et al. Petrosal sinus sampling with and without CRH for differential diagnosis of Cushing's syndrome. N Engl J Med. 1991;325(13):897-905.
  5. Lefournier V et al. Accuracy of bilateral inferior petrosal or cavernous sinuses sampling in predicting the lateralization of Cushing's disease pituitary microadenoma. J Clin Endocrinol Metab. 2003;88(1):196-203.
  6. Colao A et al. Inferior petrosal sinus sampling in the differential diagnosis of Cushing's syndrome: results of an Italian multicenter study. Eur J Endocrinol. 2001;144(5):499-507.
  7. Nieman LK et al. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008;93(5):1526-1540.
  8. Wind JJ et al. The lateralization accuracy of inferior petrosal sinus sampling in 501 patients with Cushing's disease. J Clin Endocrinol Metab. 2013;98(6):2285-2293.
  9. Machado MC et al. The inferior petrosal sinus sampling with/without desmopressin: enhancement with prolactin-to-ACTH gradient. Eur J Endocrinol. 2007;157(1):29-39.

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