Nephrology

Cockcroft-Gault eCrCl Calculator

Free Cockcroft-Gault eCrCl calculator. Adult legacy-label estimated creatinine clearance with explicit weight basis, exact µmol/L conversion, and clinical limitations.

References

  1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
  2. Sokoll LJ, Russell RM, Sadowski JA, Morrow FD. Establishment of creatinine clearance reference values for older women. Clin Chem. 1994;40(12):2276-2281.
  3. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.
  4. U.S. Food and Drug Administration. Pharmacokinetics in Patients with Impaired Renal Function - Study Design, Data Analysis, and Impact on Dosing. March 2024.
  5. National Institute of Diabetes and Digestive and Kidney Diseases. Determining Drug Dosing in Adults with Chronic Kidney Disease. Last reviewed October 2024.
  6. St Peter WL, et al. Moving forward from Cockcroft-Gault creatinine clearance to race-free estimated glomerular filtration rate to improve medication-related decision-making in adults across healthcare settings. Am J Health Syst Pharm. 2025;82(12):644-659.
  7. National Kidney Foundation. Race-Agnostic eGFR for Medication-Related Decisions: Frequently Asked Questions.
  8. Wilhelm SM, Kale-Pradhan PB. Estimating creatinine clearance: a meta-analysis. Pharmacotherapy. 2011;31(9):658-664.
  9. Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy. 2012;32(7):604-612.
  10. Bouquegneau A, et al. Creatinine-based equations for the adjustment of drug dosage in an obese population. Br J Clin Pharmacol. 2016;81(2):349-361.
  11. Cucci MD, et al. Performance of different body weights in the Cockcroft-Gault equation in critically ill patients with and without augmented renal clearance. Pharmacotherapy. 2023;43(11):1131-1138.
  12. Garimella PS, et al. Tubular Secretion of Creatinine and Risk of Kidney Failure: The MDRD Study. Am J Kidney Dis. 2021;77(6):992-994.
  13. Medicines and Healthcare products Regulatory Agency. Prescribing medicines in renal impairment: using the appropriate estimate of renal function to avoid adverse drug reactions. 18 October 2019.
  14. NHS Specialist Pharmacy Service. Calculating kidney function. Last updated 16 April 2024.

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